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KMID : 0941820130230020123
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Korean Journal of Clinical Pharmacy
2013 Volume.23 No. 2 p.123 ~ p.128
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Analysis of Ethnic Differences in Physician’s Desk Reference
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Kim Eun-Jung
Lee Kyung-Eun
Gwak Hye-Sun
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Abstract
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Purpose: The aim of study was to investigate the racial or ethnic differences in FDA-approved medications. Methods: Data on racial-based differences of drugs in PDR (Physician’s Desk Reference) were analyzed by searching with keywords, “ETHNIC” and “RACE”. Results: There were descriptions related to “ETHNIC” in product directions of 53 cases and “RACE” in 266 cases in 2010 PDR. After excluding 30 cases of duplicates, 289 cases were shown of which 28 cases were verified to demonstrate racial or ethnic differences. Drug category showing the higher racial or ethnic differences was ardiovascular drugs (7), followed by alimentary tract and metabolism drugs (6), nervous system drugs (5), and ntineoplastic and immunomodulating agents (3). Pharmacokinetic differences between race and ethnicity were observed most frequently; differences in AUC or Cmax showed in 15 drugs and clearance differences in 7 drugs. Conclusions: This study identified the racial differences in medication usage in PDR. Therefore, the results can contribute to safe use of edication in real clinical settings in regards to the racial or ethnic differences.
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KEYWORD
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ethnic, race, Physician’s Desk Refer
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